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Your Position: Home > All Other Proteins > LOXL2 > LO2-H52H3

Human LOXL2 Protein, His Tag (active enzyme)

  • Synonym
    Lysyl oxidase homolog 2,LOXL2
  • Source
    Human LOXL2, His Tag (LO2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Gln 774 (Accession # Q9Y4K0-1).
    Predicted N-terminus: Gln 26
  • Molecular Characterization
    Online(Gln 26 - Gln 774) Q9Y4K0-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 86.0 kDa. The protein migrates as 100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by reduced SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in 20 mM MES, 50 mM NaCl, pH6.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • Shipping
    This product is supplied and shipped as sterile liquid solution with dry ice, please inquire the shipping cost.
SDS-PAGE
Human LOXL2, His Tag (Cat. No. LO2-H52H3) SDS-PAGE gel

Human LOXL2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity

Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity is >5 pmol/min/μg (QC tested).

  • Background
    Lysyl oxidase homolog 2 is also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
  • Clinical and Translational Updates
      
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  • Number of Drugs in Clinical Trials:3 Details
  • Latest Research Phase:Phase 2 Clinical

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