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Your Position: Home > All Other Proteins > NKp46 > NC1-C5255

Cynomolgus NKp46 / NCR1 / CD335 Protein, Llama IgG2b Fc Tag, low endotoxin

  • Synonym
    NCR1,LY94,CD335,NK-p46,hNKp46
  • Source
    Cynomolgus NKp46, Llama IgG2b Fc Tag (NC1-C5255) is expressed from human 293 cells (HEK293). It contains AA Pro 22 - Arg 257 (Accession # Q95JB9-1).
  • Molecular Characterization
    Online(Pro 22 - Arg 257) Q95JB9-1

    This protein carries a llama IgG2b Fc tag at the C-terminus.

    The protein has a calculated MW of 54.7 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 0.01 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally Trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    After reconstitution, this product is stable after storage at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus NKp46, Llama IgG2b Fc Tag (Cat. No. NC1-C5255) SDS-PAGE gel

Cynomolgus NKp46, Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
Cynomolgus NKp46, Llama IgG2b Fc TagCynomolgus NKp46, Llama IgG2b Fc Tag (Cat. No. NC1-C5255) ELISA bioactivity

Immobilized Cynomolgus NKp46, Llama IgG2b Fc Tag (Cat. No. NC1-C5255) at 1 μg/mL (100 μL/well) can bind Anti-NKp46, hIgG4 with a linear range of 0.4-6 ng/mL (QC tested).

Please note that there may be a cross-reaction between anti-human IgG Fc antibodies and llama IgG Fc tag, also between anti-llama IgG Fc antibodies and human IgG Fc tag.
  • Background
    Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $350.00

Price(USD) : $2310.00

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