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Your Position: Home > All Other Proteins > CD24 > CD4-H52H5

Human CD24 Protein, His tag (Nanoparticle)

  • Synonym
    CD24,CD24A
  • Source
    Human CD24, His tag (Nanoparticle) (CD4-H52H5) is expressed from human 293 cells (HEK293). It contains AA Ser 27 - Gly 59 (Accession # P25063-1).
    Predicted N-terminus: Ser 27
  • Molecular Characterization

    Human CD24 Protein, His tag (Nanoparticle) is designed and expressed as nanoparticles of approximately 25 nm diameter by displaying CD24 ECD in native conformation. The nanoparticles each was coated with an average of 180 CD24 ECD.
    The nanoparticle technology allows directional and high-density display of human CD24 on the surface of nanoparticles, thus greatly enhances the immune response in vivo to otherwise poorly immunogenic epitopes.
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 34.3 kDa. The protein migrates as 43-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 0.5 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS with glycine and sodium citrate, pH8.0. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human CD24, His tag (Nanoparticle) (Cat. No. CD4-H52H5) SDS-PAGE gel

Human CD24, His tag (Nanoparticle) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
Human CD24, His tag (Nanoparticle)Human CD24, His tag (Nanoparticle) (Cat. No. CD4-H52H5) ELISA bioactivity

Immobilized Human CD24, His tag (Nanoparticle) (Cat. No. CD4-H52H5) at 5 μg/mL (100 μL/well) can bind Anti-CD24 MAb (SN3) with a linear range of 5-78 ng/mL (QC tested).

  • Background
    CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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