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Your Position: Home > Protein > TPBG > TPG-H5253

Human TPBG / 5T4 Protein, Fc Tag (MALS verified)

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  • Synonym
    TPBG,5T4,M6P1,5T4AG,WAIF1,5T4 oncofetal antigen,Trophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein
  • Source
    Human TPBG, Fc Tag(TPG-H5253) is expressed from human 293 cells (HEK293). It contains AA Ser 32 - Ser 355 (Accession # Q13641-1 ).
    Predicted N-terminus: Ser 32
  • Molecular Characterization
    TPBG Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 61.8 kDa. The protein migrates as 80-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
TPBG SDS-PAGE

Human TPBG, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
TPBG MALS images

The purity of Human TPBG, Fc Tag (Cat. No. TPG-H5253) is more than 90% and the molecular weight of this protein is around 158-192 kDa verified by SEC-MALS.

Bioactivity-ELISA
 TPBG ELISA

Immobilized Human TPBG, Fc Tag (Cat. No. TPG-H5253) at 1 μg/mL (100 μL/well) can bind Anti-TPBG Antibody, Human IgG1 with a linear range of 0.5-8 ng/mL (QC tested).

  • Background
    Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.
  • Clinical and Translational Updates

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ETD of in-stock products: 2 business days

Price(USD) : $350.00

Price(USD) : $2540.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:9 Details
  • Latest Research Phase:Phase 2 Clinical

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