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Your Position: Home > All Other Proteins > FGF-23 > FG3-H52H3

Human FGF-23 (R179Q) Protein, His Tag

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  • Synonym
    FGF23,HYPF,FGF-23,ADHR,HPDR2
  • Source
    Human FGF-23 (R179Q), His Tag (FG3-H52H3) is expressed from human 293 cells (HEK293). It contains AA Tyr 25 - Ile 251 (Accession # 出错).
    Predicted N-terminus: Tyr 25
  • Molecular Characterization
    Online-Res(Tyr 25 - Ile 251) Q9GZV9-1 (R179Q)

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 27.2 kDa.

  • Endotoxin
  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Fibroblast growth factor 23 (FGF23) is is an endocrine member of the family of FGFs and mainly produced in the bone and, upon secretion, forms a complex with a FGF receptor and coreceptor αKlotho. FGF23 can exert several endocrine functions, such as acting as a hormone on the kidney, stimulating phosphate excretion and suppressing formation of 1,25(OH)2D3, active vitamin D. Moreover, it has paracrine activities on several cell types, including neutrophils and hepatocytes. FGF23 and phosphate have been revealed to be factors relevant in cancer. FGF23 is particularly significant for those forms of cancer primarily affecting bone (e.g., multiple myeloma) or characterized by bone metastasis.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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