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Your Position: Home > All Other Proteins > IL-17 RA > Human IL-17 RA / CD217 Protein, His Tag

Human IL-17 RA / CD217 Protein, His Tag

  • Synonym
    CD217,CDw217,IL-17RA,IL17R,CANDF5,hIL-17R
  • Source
    Human IL-17 RA, His Tag (ILA-H5222) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (Accession # NP_055154.3).
    Predicted N-terminus: Leu 33
  • Molecular Characterization
    Online(Leu 33 - Trp 320) NP_055154.3

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 34.3 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >98% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss was observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human IL-17 RA, His Tag (Cat. No. ILA-H5222) SDS-PAGE gel

Human IL-17 RA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%.

Bioactivity-ELISA
Human IL-17 RA, His TagHuman IL-17 RA, His Tag (Cat. No. ILA-H5222) ELISA bioactivity

Immobilized Human IL-17A, Tag Free (Cat. No. ILA-H5118) at 0.5 μg/mL (100 μL/well) can bind Human IL-17 RA, His Tag (Cat. No. ILA-H5222) with a linear range of 4-31 ng/mL (QC tested).

  • Background
    Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested . IL 17RA associates with IL 17RC to form a signaling receptor complex for IL 17 and IL 17F . Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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