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Cynomolgus Integrin isoform alpha-7X1B beta 1 (ITGA7X1B&ITGB1) Heterodimer Protein, Tag Free&His Tag (MALS verified)

  • Synonym
    integrin alpha-7 isoform X1B beta 1,ITGA7X1B&ITGB1,ITGA7X1BB1
  • Source
    Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag (IT1-C52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 34 - Pro 1081 (ITGA7X1B) & Gln 21 - Asp 728 (ITGB1) (Accession # A0A2K5UN90-1(ITGA7X1B) & A0A2K5WHU8-1(ITGB1)).
    Predicted N-terminus: Phe 34 (ITGA7X1B) & Gln 21 (ITGB1)
  • Molecular Characterization
    Online(Phe 34 - Pro 1081 (ITGA7X1B) & Gln 21 - Asp 728 (ITGB1)) A0A2K5UN90-1 (ITGA7X1B) & A0A2K5WHU8-1 (ITGB1)

    Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag, produced by co-expression of ITGA7X1B and ITGB1, has a calculated MW of 115.1 kDa (ITGA7X1B) and 85.0 kDa (ITGB1). Subunit ITGA7X1B contains no tag but an acidic tail at the C-terminus and subunit ITGB1 contains a polyhistidine tag and a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 95-115 kDa due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag (Cat. No. IT1-C52W3) SDS-PAGE gel

Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag (Cat. No. ) MALS images

The purity of Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag (Cat. No. IT1-C52W3) is more than 90% and the molecular weight of this protein is around 208-254 kDa verified by SEC-MALS.

  • Background
    Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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