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Your Position: Home > Protein > MAGP-2 > MA2-H5254

Human MAGP-2 Protein, Fc Tag

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  • Synonym
    MAGP2,MAGP-2,MAGP2,MFAP-5,MFAP5,Microfibril-associated glycoprotein 2,MP25
  • Source
    Human MAGP-2, Fc Tag (MA2-H5254) is expressed from human 293 cells (HEK293). It contains AA Ile 22 - Leu 173 (Accession # Q13361-1).
    Predicted N-terminus: Ile 22
  • Molecular Characterization
    Online(Ile 22 - Leu 173) Q13361-1

    This protein carries a Fc tag at the C-terminus. This protein contains a furin convertase cleavage site, 149-RRLR-152, and will be partially processed into N and C-terminal fragment with calculated MW of 43.7 kDa and 29.1 kDa respectively. The protein migrates as 55-66 kDa and 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Human MAGP-2, Fc Tag (Cat. No. MA2-H5254) SDS-PAGE gel

Human MAGP-2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    MAGP-2 (Microfibril-associated glycoprotein 2), also called MFAP5 (microfibrillar associated protein 5) is a secreted, cell-associated 25 kDa mammalian member of the MFAP family of proteins. Both MAGP-1 and MAGP-2 bind and covalently crosslink Fibrillin-1 and -2 through the Cys-rich binding domain. Functionally, the MAGP-2 RGD motif binds to the integrin alpha v beta 3, allowing cell attachment to microfibrils. MAGP‑2 is thought to facilitate microfibril assembly and induce elastin fiber formation. Through its binding to EGF repeats, MAGP‑2 mediates the metalloproteinase-dependent release of Jagged1, and the metalloproteinase-independent release of Notch extracellular domains. In endothelial cells, MAGP-2 promotes angiogenic sprouting by inhibiting Notch signaling, by binding to integrin alpha v beta 3 (which then enhances VEGF signaling), and/or enhancing the endothelial cell response to FGF basic and EGF. In ovarian cancer, MAGP-2 expression is associated with cancer cell survival, increased microvessel density, and poor prognosis.
  • Clinical and Translational Updates
  • Please contact us via if you have any question on this product.

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Price(USD) : $350.00

Price(USD) : $2540.00

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