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Your Position: Home > Others > OSCAR > OSR-H52H3

Human OSCAR / PIgR-3 Protein, His Tag (MALS verified)

  • Synonym
    OSCAR,Osteoclast-associated receptor,PIGR3,PIgR-3,Poly-Ig receptor 3
  • Source
    Human OSCAR, His Tag (OSR-H52H3) is expressed from human 293 cells (HEK293). It contains AA Asp 19 - Asn 229 (Accession # Q8IYS5-2).
    Predicted N-terminus: Asp 19
  • Molecular Characterization
    Online(Asp 19 - Asn 229) Q8IYS5-2

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 25.0 kDa. The protein migrates as 33-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human OSCAR, His Tag (Cat. No. OSR-H52H3) SDS-PAGE gel

Human OSCAR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
Human OSCAR, His Tag (Cat. No. ) MALS images

The purity of Human OSCAR, His Tag (Cat. No. OSR-H52H3) is more than 90% and the molecular weight of this protein is around 27-40 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human OSCAR, His TagHuman OSCAR, His Tag (Cat. No. OSR-H52H3) ELISA bioactivity

Immobilized Native Human Collagen I protein at 2 μg/mL (100 μL/well) can bind Human OSCAR, His Tag (Cat. No. OSR-H52H3) with a linear range of 0.039-1.25 μg/mL (QC tested).

  • Background
    OSCAR (Osteoclast-associated immunoglobulin-like receptor), also known as PIgR-3 (polymeric immunoglobulin-like receptor), is a type I transmembrane protein of the leukocyte receptor complex (LRC) family. OSCAR is specifically expressed by pre-osteoclasts and signals via FcR gamma. OSCAR co-stimulates one of the major FcR gamma -associated pathways required for osteoclastogenesis in vivo. Collagen type I and collagen type II serve as ligands for OSCAR. OSCAR binds to specific motifs within fibrillary collagens in the extracellular matrix (ECM). OSCAR promoted osteoclastogenesis in vivo, and its binding to the collagen motif led to signaling that increased numbers of osteoclasts in culture. OSCAR contains two immunoglobulin-like domains, D1 and D2. Direct binding assays on OSCAR molecules showed that D2, but not D1, is critical for collagen binding. OSCAR may contribute to the pathogenesis and severity of a number of diseases including osteoporosis, atherosclerosis, chronic obstructive pulmonary disease and rheumatoid arthritis.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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