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Your Position: Home > CKP > CLEC5A > CLA-H5243

Human CLEC5A / MDL-1 Protein, His Tag (MALS & SPR verified)

  • Synonym
    CLEC5A,CLECSF5,superfamilymember 5,C-type lectin domain family 5, member A,MDL1,MDL-1,DAP12-associating lectin 1
  • Source
    Human CLEC5A, His Tag(CLA-H5243) is expressed from human 293 cells (HEK293). It contains AA Pro 28 - Lys 188 (Accession # Q9NY25-1 ).
    Predicted N-terminus: His
  • Molecular Characterization

    This protein carries a polyhistidine tag at the N-terminus

    The protein has a calculated MW of 39.0 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
CLEC5A SDS-PAGE

Human CLEC5A, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
CLEC5A MALS images

The purity of Human CLEC5A, His Tag (Cat. No. CLA-H5243) is more than 90% and the molecular weight of this protein is around 70-90 kDa verified by SEC-MALS.

Bioactivity-SPR
 CLEC5A SPR

Human Galectin-9 immobilized on CM5 Chip can bind Human CLEC5A, His Tag (Cat. No. CLA-H5243) with an affinity constant of 57.9 pM as determined in a SPR assay (Biacore 8K) (QC tested).

  • Background
    CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily.CLEC5A is expressed on monocytes, macrophages, and neutrophils. Its expression is up-regulated on monocytes in rheumatoid arthritis. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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