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Your Position: Home > TME Relevant Pathway > Integrin alpha V beta 6 > IT6-C52W9

Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free

  • Synonym
    Integrin alpha V beta 6,ITGAV&ITGB6
  • Source
    Cynomolgus ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (IT6-C52W9) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 993 (ITGAV) & Gly 22 - Pro 709 (ITGB6) (Accession # A0A2K5WCD3-1(ITGAV) & A0A2K5TZ36-1(ITGB6)).
    Predicted N-terminus: Phe 31 (ITGAV) & Gly 22 (ITGB6)
  • Molecular Characterization
    Online(Phe 31 - Pro 993 (ITGAV) & Gly 22 - Pro 709 (ITGB6)) A0A2K5WCD3-1 (ITGAV) & A0A2K5TZ36-1 (ITGB6)

    Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 113.1 kDa (ITGAV) and 79.0 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gly 22 (ITGB6). The non-reducing (NR) protein migrates as 135-145 kDa (ITGAV) & 85-95 kDa (ITGB6) respectively due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH8.0. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT6-C52W9) SDS-PAGE gel

Cynomolgus ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
Cynomolgus ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag FreeCynomolgus ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT6-C52W9) ELISA bioactivity

Immobilized Cynomolgus ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT6-C52W9) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Latent TGF-Beta 1, His,Avitag (Cat. No. TG1-H82Qb) with a linear range of 0.2-10 ng/mL (QC tested).

Cynomolgus ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag FreeCynomolgus ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT6-C52W9) ELISA bioactivity

Immobilized Fibronectin at 5 μg/mL (100 μL/well) can bind Cynomolgus ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT6-C52W9) with a linear range of 0.078-1.25 μg/mL (Routinely tested).

  • Background
    Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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