Product Details
Synonyms
TNFRSF10A, TRAIL-R1, CD261, APO2, DR4
Source
Human TRAIL R1, His Tag (TR1-H5228) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Asn 239 (Accession # O00220-1).
Predicted N-terminus: Ala 24
Request for sequenceMolecular Characterization

Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 24.8 kDa. The protein migrates as 20-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
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Performance Data
SDS-PAGE

Human TRAIL R1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.
Bioactivity-ELISA

Immobilized Human TRAIL R1, His Tag (Cat. No. TR1-H5228) at 5 μg/mL (100 μL/well) can bind Human TRAIL, Mouse IgG2a Fc Tag with a linear range of 2-63 ng/mL (QC tested).
Protocol
Bioactivity-BLI

Loaded Human TRAIL R1, His Tag (Cat. No. TR1-H5228) on HIS1K Biosensor, can bind Human TRAIL with an affinity constant of 0.583 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Protocol
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Background
Recent Advances
- English Name:
Tumor necrosis factor receptor superfamily member 10A
- Category:
- Approved Drugs:
1 Details
- Drugs in Clinical Trials:
3 Details
- Highest Development Stage:
Approved
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