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Your Position: Home > Protein > KIR3DL3 > KI3-H5259

Human KIR3DL3 / CD158z Protein, Fc Tag

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  • Synonym
    Killer cell immunoglobulin-like receptor 3DL3,CD158 antigen-like family member Z,Killer cell inhibitory receptor 1,CD158z,KIR3DL3,KIR3DL7,KIRC1
  • Source
    Human KIR3DL3, Fc Tag (KI3-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Leu 322 (Accession # Q8N743-1).
    Predicted N-terminus: Gln 26
  • Molecular Characterization
    Online(Gln 26 - Leu 322) Q8N743-1

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 58.7 kDa. The protein migrates as 66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Human KIR3DL3, Fc Tag (Cat. No. KI3-H5259) SDS-PAGE gel

Human KIR3DL3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    the inhibitory KIR surface receptors possessing three extracellular immunoglobin (Ig) domains (3D) and only one inhibitory motif within the long cytoplasmic domain (L) due to a premature stop codon. Moreover, exon 6 of KIR3DL3 encoding the stem part of the receptor is also absent, which differs from other inhibitory KIRs. Understanding the function of KIR3DL3 is further complicated by the unknown identity of the specific ligand, but its importance is highlighted by its presence in all human KIR haplotypes with 120 distinct polymorphic alleles of the coding sequence [
  • Clinical and Translational Updates
  • Please contact us via if you have any question on this product.

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