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Your Position: Home > variant-specific antibody > Spike RBD > SPD-M370

Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM110) (Delta Specific)

  • Source
    Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (Delta Specific) is a chimeric monoclonal antibody recombinantly expressed from HEK293 cells, which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The mouse monoclonal antibody was obtained from a mouse immunized with recombinant SARS-CoV-2 Spike RBD protein. The antibody is specific against the Delta (B.1.617.2/AY.4) variant of SARS-CoV-2, and has no binding with the spike RBD of the wild type virus and the Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Omicron (B.1.1.529/BA.1) variant.
  • Isotype
    Human IgG1/kappa
  • Specificity
    This product is a specific antibody against SARS-CoV-2 Spike protein RBD domain. Cross-reactivity with Spike protein RBD domain of other coronaviruses, including SARS-CoV, MERS-CoV, HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1, has not been tested.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 . Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (Delta Specific) (Cat. No. SPD-M370) SDS-PAGE gel

Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (Delta Specific) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA
Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (Delta Specific)Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (Delta Specific) (Cat. No. SPD-M370) ELISA bioactivity

Immobilized SARS-CoV-2 Spike Trimer (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N) His Tag (Cat. No. SPN-C52He) at 2μg/mL (100μL/well) can bind Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (Delta Specific) (Cat. No. SPD-M370) with a linear range of 0.2-3 ng/mL. The antibody does not bind S protein of WT (Cat. No. SPN-C52H9), Alpha (Cat. No.SPN-C52H6), Beta (Cat. No.SPN-C52Hk), Delta (Cat. No. SPD-C52Hh), Gamma (Cat. No. SPN-C52Hg) and Omicron (Cat. No. SPN-C52Hz) (Routinely tested).

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (Delta Specific) (Cat. No. SPD-M370) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind SARS-CoV-2 Spike Trimer, His Tag (Cat. No. SPN-C52He) with an affinity constant of 0.211 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Human_FcRn_Heterodimer_Protein_SPR

Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (Delta Specific) (Cat. No. SPD-M370) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind SARS-CoV-2 Spike RBD (L452R, T478K), His Tag (Cat. No. SPD-C52Hh) with an affinity constant of 3.14 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

  • Background
    It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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ETD of in-stock products: 2 business days

Price(USD) : $790.00

Price(USD) : $4980.00

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