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Your Position: Home > Cytokines > CCL22 > CC2-H5257

Human CCL22 / MDC Protein, Fc Tag

  • Synonym
    MDC/ABCD-1/SCYA22/STCP-1/DC/B-CK/A-152E5.1
  • Source
    Human CCL22, Fc Tag (CC2-H5257) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Gln 93 (Accession # O00626-1).
    Predicted N-terminus: Gly 25
  • Molecular Characterization
    Online(Gly 25 - Gln 93) O00626-1

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 34.5 kDa. The protein migrates as 35-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human CCL22, Fc Tag (Cat. No. CC2-H5257) SDS-PAGE gel

Human CCL22, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.
  • Clinical and Translational Updates
      
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