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Your Position: Home > CKP > GFR alpha-like > GFA-C52H6

Cynomolgus GFR alpha-like Protein, His Tag

  • Synonym
    GFR alpha like,GFR alpha-like,GFRAL,GRAL
  • Source
    Cynomolgus GFR alpha-like, His Tag (GFA-C52H6) is expressed from human 293 cells (HEK293). It contains AA Thr 21 - Glu 351 (Accession # XP_015304775.1).
    Predicted N-terminus: Thr 21
  • Molecular Characterization
    Online(Thr 21 - Glu 351) XP_015304775.1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 39.6 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus GFR alpha-like, His Tag (Cat. No. GFA-C52H6) SDS-PAGE gel

Cynomolgus GFR alpha-like, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
Cynomolgus GFR alpha-like, His TagCynomolgus GFR alpha-like, His Tag (Cat. No. GFA-C52H6) ELISA bioactivity

Immobilized Cynomolgus GFR alpha-like, His Tag (Cat. No. GFA-C52H6) at 5 μg/mL (100 μL/well) can bind Human GDF-15, Fc Tag (Cat. No. GD5-H5269) with a linear range of 0.2-8 ng/mL (QC tested).

  • Background
    GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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