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Your Position: Home > Protein > SIGIRR > SIR-H5255

Human SIGIRR Protein, Fc Tag (MALS verified)

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  • Synonym
    Single Ig IL-1-related receptor,Single Ig IL-1R-related molecule,Single immunoglobulin domain-containing IL1R-related protein,Toll/interleukin-1 receptor 8,TIR8
  • Source
    Human SIGIRR, Fc Tag (SIR-H5255) is expressed from human 293 cells (HEK293). It contains AA Met 1 - His 118 (Accession # Q6IA17-1).
    Predicted N-terminus: Met 1
  • Molecular Characterization
    Online(Met 1 - His 118) Q6IA17-1

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 39.0 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Human SIGIRR, Fc Tag (Cat. No. SIR-H5255) SDS-PAGE gel

Human SIGIRR, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

Human SIGIRR, Fc Tag (Cat. No. ) MALS images

The purity of Human SIGIRR, Fc Tag (Cat. No. SIR-H5255) is more than 95% and the molecular weight of this protein is around 85-120 kDa verified by SEC-MALS.

  • Background
    Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
  • Clinical and Translational Updates
  • Please contact us via if you have any question on this product.

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Price(USD) : $260.00

Price(USD) : $1980.00

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