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Product Details
Synonyms
FCER1A, FCE1A, FcERI
Source
Cynomolgus Fc epsilon RI alpha, Fc Tag (FCA-C5255) is expressed from human 293 cells (HEK293). It contains AA Val 29 - Lys 204 (Accession # A0A7N9DA09-1).
Predicted N-terminus: Val 29
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 46.9 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.
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Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Cynomolgus Fc epsilon RI alpha, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.
Bioactivity-ELISA
Immobilized Cynomolgus Fc epsilon RI alpha, Fc Tag (Cat. No. FCA-C5255) at 5 μg/mL (100 μL/well) can bind Cynomolgus IgE Fc Protein, His Tag (Cat. No. IGE-C52H3) with a linear range of 0.6-20 ng/mL (Routinely tested).
Protocol
Bioactivity-BLI
Loaded Cynomolgus Fc epsilon RI alpha, Fc Tag (Cat. No. FCA-C5255) on AHC Biosensor, can bind Immunoglobulin E, Human Plasma with an affinity constant of 1.65 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
IgE Fc receptor, alpha-subunit
- Category：
- Approved Drugs：
1 Details
- Drugs in Clinical Trials：
1 Details
- Highest Development Stage：
Approved
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