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Your Position: Home > Cytokines > CCL3 > CC3-H5249

Human CCL3 / MIP-1 alpha Protein, His Tag

  • Synonym
    C-C motif chemokine 3,MIP1-(a),AI323804,CCL3,chemokine (C-C motif) ligand 3,G0S19-1,LD78a,LD78alpha,MIP1 alpha,MIP-1 alpha,MIP1A,MIP-1alpha,MIP1-alpha
  • Source
    Human CCL3, His Tag(CC3-H5249) is expressed from E.coli cells. It contains AA Ser 24 - Ala 92 (Accession # P10147-1 ).
    Predicted N-terminus: Met
  • Molecular Characterization
    CCL3 Structure

    This protein carries a polyhistidine tag at the N-terminus

    The protein has a calculated MW of 9.7 kDa. The protein migrates as 12-13 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 0.1 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris,150 mM NaCl,0.2 M Arginine,1 mM EDTA,pH8.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
CCL3 SDS-PAGE

Human CCL3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    CCL3, also know as MIP-1-alpha, is monokine with inflammatory and chemokinetic properties. CCL3 is an important chemokine implicated in both immune surveillance and tolerance, has emerged as a prognostic biomarker in both solid and hematological malignancies. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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  • Number of Drugs in Clinical Trials:0 Details
  • Latest Research Phase:Pending

Datasheet & Documentation

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DMF (Drug Master File)

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