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Your Position: Home > Protein > DLL3 > DL3-H52Hz

Human DLL3 (312-492) Protein, His Tag

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  • Synonym
    Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3
  • Source
    Human DLL3 (312-492) , His Tag(DL3-H52Hz) is expressed from human 293 cells (HEK293). It contains AA Ser 312 - Leu 492 (Accession # Q9NYJ7-1 ).
    Predicted N-terminus: Ser 312
  • Molecular Characterization
    DLL3 Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 20.4 kDa. The protein migrates as 21-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in PBS, pH7.4.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
SDS-PAGE
DLL3 SDS-PAGE

Human DLL3 (312-492) , His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
 DLL3 ELISA

Immobilized Human DLL3 (312-492) , His Tag (Cat. No. DL3-H52Hz) at 1 μg/mL (100 μL/well) can bind Anti-DLL3 Antibody (specific Binding EGFs of DLL3), Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

  • Background
    Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.
  • Clinical and Translational Updates

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:11 Details
  • Latest Research Phase:NDA/BLA

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