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Product Details
Synonyms
Neuropilin-2, NRP2, VEGF165R2, Neuropilin2, Vascular endothelial cell growth factor 165 receptor 2
Source
Human Neuropilin-2, His Tag (NR2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Pro 864 (Accession # O60462-1).
Predicted N-terminus: Arg 21
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 97.0 kDa. The protein migrates as 105-125 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Human Neuropilin-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Human Neuropilin-2, His Tag (Cat. No. NR2-H52H3) is more than 95% and the molecular weight of this protein is around 98-128 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Human Neuropilin-2, His Tag (Cat. No. NR2-H52H3) at 2 μg/mL (100 μL/well) can bind Biotinylated Human VEGF165, His,Avitag (Cat. No. VE5-H82Q0) with a linear range of 0.005-0.625 μg/mL (QC tested).
Protocol
Bioactivity-SPR
Human VEGF-C Protein, His Tag (Cat. No. VEC-H52H3) immobilized on CM5 Chip can bind Human Neuropilin-2, His Tag (Cat. No. NR2-H52H3) with an affinity constant of 8.36 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Neuropilin 2
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
1 Details
- Highest Development Stage：
Phase 3 Clinical
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