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Your Position: Home > Others > Neuropilin-2 > NR2-H52H3

Human Neuropilin-2 / NRP2 Protein, His Tag (MALS verified)

  • Synonym
    Neuropilin-2,NRP2,VEGF165R2,Neuropilin2,Vascular endothelial cell growth factor 165 receptor 2
  • Source
    Human Neuropilin-2, His Tag (NR2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Pro 864 (Accession # O60462-1).
    Predicted N-terminus: Arg 21
  • Molecular Characterization
    Online(Arg 21 - Pro 864) O60462-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 97.0 kDa. The protein migrates as 105-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human Neuropilin-2, His Tag (Cat. No. NR2-H52H3) SDS-PAGE gel

Human Neuropilin-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Human Neuropilin-2, His Tag (Cat. No. ) MALS images

The purity of Human Neuropilin-2, His Tag (Cat. No. NR2-H52H3) is more than 90% and the molecular weight of this protein is around 98-128 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human Neuropilin-2, His TagHuman Neuropilin-2, His Tag (Cat. No. NR2-H52H3) ELISA bioactivity

Immobilized Human Neuropilin-2, His Tag (Cat. No. NR2-H52H3) at 2 μg/mL (100 μL/well) can bind Biotinylated Human VEGF165, His,Avitag (Cat. No. VE5-H82Q0) with a linear range of 0.005-0.625 μg/mL (QC tested).

  • Background
    Neuropilin-1 (Npn-1, previously known as neuropilin) and Neuropilin-2 (previously known as Npn-1-related molecule) are type I transmembrane proteins that bind distinct members of the class III secreted semaphorin subfamily that are implicated in repulsive axon guidance. Neuropilin extracellular domains contain two CUB (complement-binding) domains, two domains with homology to coagulation factors V and VIII, and a MAM (meprin) domain. In the absence of ligands, neuropilins can form homo- and hetero-oligomers via their MAM domains. Expression in developing neurons of the central and peripheral nervous systems is somewhat overlapping but distinct. Npn-1 and Npn-2 are also receptors for VEGF165 on endothelial and tumor cells.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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