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Your Position: Home > Aneuro > TDP-43 > TD3-H5145

Human TDP-43 Protein, His Tag

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  • Synonym
    TAR DNA-binding protein 43
  • Source
    Human TDP-43, His Tag (TD3-H5145) is expressed from E.coli cells. It contains AA Met 1 - Met 414 (Accession # Q13148-1).
    Predicted N-terminus: Met
  • Molecular Characterization
    Online-Res(Met 1 - Met 414) Q13148-1

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 47.6 kDa.

  • Endotoxin
  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • Shipping
    This product is supplied and shipped as sterile liquid solution with dry ice, please inquire the shipping cost.
  • Background
    TDP-43, the transactive response (TAR)-DNA binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1. It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member. involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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