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Your Position: Home > All Other Proteins > Cathepsin S > CTS-H52H9

Human Cathepsin S / CTSS Protein, His Tag (active enzyme, MALS verified)

  • Synonym
    CTSS,Cathepsin S
  • Source
    Human Cathepsin S, His Tag (CTS-H52H9) is expressed from human 293 cells (HEK293). It contains AA Gln 17 - Ile 331 (Accession # P25774-1).
    Predicted N-terminus: Gln 17
  • Molecular Characterization
    Online(Gln 17 - Ile 331) P25774-1

    This protein carries a polyhistidine tag at the C-terminus. This protein contains an Activation peptide(17 Q-114 I), and will be partially processed into Pro form with calculated MW of 39 kDa and mature form with calculated MW of 28 kDa under reducing (R) condition.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 12.5 mM MES, 75 mM NaCl, pH6.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Storage

    Please avoid repeated freeze-thaw cycles and long term storage after opening.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. The product MUST be stored at-20°C after being opened.
  • Shipping
    This product is supplied and shipped as sterile liquid solution with dry ice, please inquire the shipping cost.
SDS-PAGE
Human Cathepsin S, His Tag (Cat. No. CTS-H52H9) SDS-PAGE gel

Human Cathepsin S, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
Human Cathepsin S, His Tag (Cat. No. ) MALS images

The purity of Human Cathepsin S, His Tag (Cat. No. CTS-H52H9) is more than 90% and the molecular weight of this protein is around 70-92 kDa verified by SEC-MALS.

Bioactivity

Measured by its ability to cleave the fluorogenic peptide substrate, Mca­RPKPVE­Nval­WRK(Dnp)­NH2. The specific activity is >1200 pmol/min/µg, as measured under the described conditions (QC tested).

  • Background
    Cathepsin S is also known as CTSS, which is a member of the peptidase C1 family. Cathepsin S is a lysosomal cysteine protease that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. Cathepsin S can function as an elastase over a broad pH range in alveolar macrophages. The catalytic activity of cathepsin S is similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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  • Latest Research Phase:Discontinued

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