Human IL-20 R alpha Protein, His Tag (MALS & SPR verified)

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Cat. No. / Size
Price
Qty
ILA-H52H3-100ug
$390.00
ILA-H52H3-1mg (500ug X 2)
$2575.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    Interleukin-20 receptor subunit alpha, IL-20 receptor subunit alpha, IL-20R-alpha, IL-20RA, Cytokine receptor class-II member 8, Cytokine receptor family 2 member 8, CRF2-8, IL-20R1, ZcytoR7

  • Source

    Human IL-20 R alpha Protein, His Tag (ILA-H52H3) is expressed from human 293 cells (HEK293). It contains AA Val 30 - Lys 250 (Accession # Q9UHF4-1).

    Predicted N-terminus: Val 30

    Request for sequence
  • Molecular Characterization

    IL-20 R alpha Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 27.1 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    IL-20 R alpha SDS-PAGE

    Human IL-20 R alpha Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    IL-20 R alpha SEC-MALS

    The purity of Human IL-20 R alpha Protein, His Tag (Cat. No. ILA-H52H3) is more than 85% and the molecular weight of this protein is around 35-50 kDa verified by SEC-MALS.

    Report
  • Bioactivity-SPR

     IL-20 R alpha SPR

    Human IL-20, His Tag (Cat. No. IL0-H5243) immobilized on CM5 Chip can bind Human IL-20 R alpha Protein, His Tag (Cat. No. ILA-H52H3) with an affinity constant of 3.31 μM as determined in a SPR assay (Biacore 8K) (QC tested).

    Protocol

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Background

IL-20 R alpha (Interleukin-20 receptor subunit alpha) forms a functional heterodimer with the IL-20 beta subunit, and transduces ligand-binding at least in part through STAT3 activation. The IL-20 subfamily of cytokines and receptors are members of the larger IL-10 family, which are grouped together based on their utilization of common receptor subunits, similarities in their target-cell profiles, and biological functions. This subfamily consists of the cytokines, IL-19, IL-20, IL-22, IL-24, and IL-26, as well as the receptors, IL-20RA, IL-20RB, IL-10RB, and IL-22RA1.

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