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Your Position: Home > Protein > IL-39 > IL9-H5259

Human IL-39 Protein, Fc Tag (MALS verified)

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  • Synonym
    EBI3,IL39,IL-39EBI3,IL39p19,Interleukin-39,IL-39
  • Source
    Human IL-39, Fc Tag(IL9-H5259) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Lys 229 & Arg 20 - Pro 189 (Accession # Q14213-1 (IL-27 beta) & Q9NPF7-1 (IL-23 alpha)).
    Predicted N-terminus: Arg 21
  • Molecular Characterization

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 69.4 kDa. The protein migrates as 75-85 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
IL-39 SDS-PAGE

Human IL-39, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
IL-39 MALS images

The purity of Human IL-39, Fc Tag (Cat. No. IL9-H5259) is more than 85% and the molecular weight of this protein is around 145-175 kDa verified by SEC-MALS.

Bioactivity-ELISA
 IL-39 ELISA

Immobilized Human IL-39, Fc Tag (Cat. No. IL9-H5259) at 1 μg/mL (100 μL/well) can bind Anti-IL23A MAb (Cat. No. IL9-H5259) with a linear range of 10-156 ng/mL (QC tested).

  • Background
    Interleukin 39 (IL-39) is a new member of the IL-12 family and is composed of IL-23p19 and Ebi3 subunits.The two subunits, IL-23p19 and Ebi3, are shared with IL-23 and IL-27/IL-35. IL-23p19 is a four-helix bun dle and has homology with IL-6 and granulocyte colony stimulating factor. Ebi3 was first identified in B lympho cytes infected with EB virus. Some studies have reported that the combination of IL-23R and gp130 forms the IL-39 receptor. At present, a research on IL-39 is still in its initial stage, and many issues have not been solved.
  • Clinical and Translational Updates

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Price(USD) : $350.00

Price(USD) : $2310.00

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