Login Register
icon_bulk_orderBulk order Acrobiosystems for English
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Immune Checkpoint Proteins > OX40 Ligand > OXL-R5249

Rabbit OX40 Ligand / TNFSF4 Protein, His Tag (active trimer) (MALS verified)

  • Synonym
    OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1,CD134 ligand,CD134L
  • Source
    Rabbit OX40 Ligand, His Tag (OXL-R5249) is expressed from human 293 cells (HEK293). It contains AA Gln 45 - Pro 187 (Accession # O02765-1).
    Predicted N-terminus: His
  • Molecular Characterization

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 51.2 kDa. The protein migrates as 50-60 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Rabbit OX40 Ligand, His Tag (Cat. No. OXL-R5249) SDS-PAGE gel

Rabbit OX40 Ligand, His Tag on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Rabbit OX40 Ligand, His Tag (Cat. No. ) MALS images

The purity of Rabbit OX40 Ligand, His Tag (Cat. No. OXL-R5249) is more than 90% and the molecular weight of this protein is around 50-65 kDa verified by SEC-MALS.

Bioactivity-ELISA
Rabbit OX40 Ligand, His TagRabbit OX40 Ligand, His Tag (Cat. No. OXL-R5249) ELISA bioactivity

Immobilized Rabbit OX40 Ligand, His Tag (Cat. No. OXL-R5249) at 2 μg/mL (100 μL/well) can bind Human OX40, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. OX0-H5252) with a linear range of 1-39 ng/mL (QC tested).

  • Background
    Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Comments (0)


ETD of in-stock products: 2 business days

Price(USD) : $290.00

Price(USD) : $1980.00

Recommended Products
Monoclonal Anti-His Tag Antibody

Price(USD) : $250.00

Price(USD) : $1580.00

HRP conjugated Anti-His Tag Antibody

Price(USD) : $250.00

Price(USD) : $1680.00

Promotion & Exhibitions



Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:5 Details
  • Latest Research Phase:Phase 2 Clinical

Datasheet & Documentation

Request for DMF
DMF (Drug Master File)

Contact Us

+1  800-810-0816 (US)
+86 400-682-2521 (AP)

New Product Launch

Questions & Comments

This web search service is supported by Google Inc.

totop
Call us
Call us
North America: +1 800-810-0816 (Toll Free)
Asia & Pacific: +86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message