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Product Details
Synonyms
DPP4, ADABP, ADCP2, CD26, DPPIV, TP103
Source
Cynomolgus DPPIV, His Tag (DP4-C52H9) is expressed from human 293 cells (HEK293). It contains AA Asn 29 - Pro 766 (Accession # F6VRB0-1).
Predicted N-terminus: Asn 29
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 86.9 kDa. The protein migrates as 100-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH8.0 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Cynomolgus DPPIV, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
SEC-MALS
The purity of Cynomolgus DPPIV, His Tag (Cat. No. DP4-C52H9) is more than 90% and the molecular weight of this protein is around 185-215 kDa verified by SEC-MALS.
Report
Bioactivity-SPR
MERS S1 protein, His Tag (Cat. No. S1N-M52H5) immobilized on CM5 Chip can bind Cynomolgus DPPIV, His Tag (Cat. No. DP4-C52H9) with an affinity constant of 60.7 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
Bioactivity
Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin (GP-AMC). The specific activity is >3,500 pmol/min/μg (QC tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Dipeptidyl peptidase IV
- Category：
- Approved Drugs：
41 Details
- Drugs in Clinical Trials：
40 Details
- Highest Development Stage：
Approved
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