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Your Position: Home > Protein > Tau > TAU-H5117

Human Tau-441 / 2N4R Protein, Tag Free (MALS verified)

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  • Synonym
    DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU
  • Source
    Human Tau-441, Tag Free(TAU-H5117) is expressed from E. coli cells. It contains AA Met 1 - Leu 441 (Accession # P10636-8 ).
    Predicted N-terminus: Met 1
  • Molecular Characterization
    Tau Structure

    This protein carries no "tag".

    The protein has a calculated MW of 45.8 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Sterility
    The sterility testing was performed by membrane filtration method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, 1 mM DTT, 1 mM EDTA, pH7.5.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
SDS-PAGE
Tau SDS-PAGE

Human Tau-441, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
Tau MALS images

The purity of Human Tau-441, Tag Free (Cat. No. TAU-H5117) is more than 90% and the molecular weight of this protein is around 38-55 kDa verified by SEC-MALS.

Bioactivity-ThT Assay
 Tau THT

Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time when tau wild-type monomers (Cat. No. TAU-H5117) are combined with tau wild-type Pre-formed Fibrils (Cat. No. TAU-H5115) (Routinely tested).

  • Background
    Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.
  • Clinical and Translational Updates

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