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Your Position: Home > FcR > Fc epsilon RI alpha > FCA-C52H9

Cynomolgus Fc epsilon RI alpha Protein, His Tag (SPR verified)

  • Synonym
    FCER1A,FCE1A,FcERI
  • Source
    Cynomolgus Fc epsilon RI alpha, His Tag (FCA-C52H9) is expressed from human 293 cells (HEK293). It contains AA Val 29 - Lys 204 (Accession # A0A7N9DA09-1).
    Predicted N-terminus: Val 29
  • Molecular Characterization
    Online(Val 29 - Lys 204) A0A7N9DA09-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 22.3 kDa. The protein migrates as 35-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus Fc epsilon RI alpha, His Tag (Cat. No. FCA-C52H9) SDS-PAGE gel

Cynomolgus Fc epsilon RI alpha, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Cynomolgus Fc epsilon RI alpha, His Tag (Cat. No. FCA-C52H9) immobilized on CM5 Chip can bind Human IgE Fc, His Tag (Cat. No. IGE-H52H9) with an affinity constant of 0.226 nM as determined in a SPR assay (Biacore 8K) (QC tested).

  • Background
    High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is also known as Fc-epsilon RI-alpha (FcERI), IgE Fc receptor subunit alpha, FCE1A. FCER1A contains two Ig-like (immunoglobulin-like) domains. FCER1A binds to the Fc region of immunoglobulins epsilon and is a high affinity receptor. FCER1A is responsible for initiating the allergic response, which binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. FCER1A plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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  • Number of Drugs in Clinical Trials:0 Details
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