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Your Position: Home > TME Relevant Pathway > Integrin alpha 1 beta 1 > IT1-R52W7

Rat Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein, His Tag&Tag Free

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  • Synonym
    Integrin alpha 1 beta 1,ITGA1&ITGB1
  • Source
    Rat ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-R52W7) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Pro 1142 (ITGA1) & Gln 21 - Asp 729 (ITGB1) (Accession # P18614-1(ITGA1) & P49134-1(ITGB1)).
    Predicted N-terminus: Phe 29 (ITGA1) & Gln 21 (ITGB1)
  • Molecular Characterization
    Online-Res(Phe 29 - Pro 1142 (ITGA1) & Gln 21 - Asp 729 (ITGB1)) P18614-1 (ITGA1) & P49134-1 (ITGB1)

    Rat ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA1 and ITGB1, has a calculated MW of 130.0 kDa (ITGA1) and 83.7 kDa (ITGB1). Subunit ITGA1 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus.

  • Endotoxin
  • Formulation

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  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Integrin alpha-1/beta-1 is a receptor for laminin and collagen. The Integrin alpha-1/beta-1 and Integrin alpha-2/beta-1 integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $410.00

Price(USD) : $2880.00

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  • Number of Drugs in Clinical Trials:1 Details
  • Latest Research Phase:Phase 2 Clinical

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