Human BMPR-1A / ALK-3 Protein, His Tag (MALS verified)

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Cat. No. / Size
Price
Qty
AL3-H52H9-200ug
$270.00
AL3-H52H9-1mg (500ug X 2)
$1235.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    BMPR-1A, ALK-3, ACVRLK3, CD292, SKR5

  • Source

    Human BMPR-1A, His Tag (AL3-H52H9) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Arg 152 (Accession # P36894-1 ).

    Predicted N-terminus: Gln 24

    Request for sequence
  • Molecular Characterization

    BMPR-1A Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 16.1 kDa. The protein migrates as 25-29 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    BMPR-1A SDS-PAGE

    Human BMPR-1A, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    BMPR-1A SEC-MALS

    The purity of Human BMPR-1A, His Tag (Cat. No. AL3-H52H9) is more than 95% and the molecular weight of this protein is around 18-26 kDa verified by SEC-MALS.

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Background

The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.

Recent Advances

 
Drug Development Progress
  • English Name:

    Bone morphogenetic protein receptor type-1A

  • Category:

  • Approved Drugs:

    2 Details

  • Drugs in Clinical Trials:

    2 Details

  • Highest Development Stage:

    Approved

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