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Your Position: Home > Cytokines > IL-22 R alpha 1 > IL1-H5258

Human IL-22 R alpha 1 Protein, Fc Tag

  • Synonym
    Interleukin-22 receptor subunit alpha-1,IL-22 receptor subunit alpha-1,IL-22R-alpha-1,IL-22RA1,Cytokine receptor class-II member 9,Cytokine receptor family 2 member 9,CRF2-9,ZcytoR11,IL22RA1 ,IL22R
  • Source
    Human IL-22 R alpha 1, Fc Tag (IL1-H5258) is expressed from human 293 cells (HEK293). It contains AA His 16 - Thr 228 (Accession # Q8N6P7-1).
  • Molecular Characterization
    Online(His 16 - Thr 228) Q8N6P7-1

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 50.9 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with Trehalose as protectant.

    Contact us for customized product form or formulation.

  • Storage

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human IL-22 R alpha 1, Fc Tag (Cat. No. IL1-H5258) SDS-PAGE gel

Human IL-22 R alpha 1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
Human IL-22 R alpha 1, Fc TagHuman IL-22 R alpha 1, Fc Tag (Cat. No. IL1-H5258) ELISA bioactivity

Immobilized Human IL-22 R alpha 1, Fc Tag (Cat. No. IL1-H5258) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-22, His,Avitag (Cat. No. IL2-H8247) with a linear range of 0.02-1.25 μg/mL (QC tested).

  • Background
    Interleukin-22 receptor subunit alpha-1(IL22RA1) is a component of the receptor for IL20, IL22 and IL24.Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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