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Your Position: Home > TME Relevant Pathway > Integrin alpha V beta 3 > IT3-R52E2

Rat Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His Tag&Tag Free (MALS verified)

  • Synonym
    Integrin alpha V beta 3,ITGAV&ITGB3
  • Source
    Rat ITGAV&ITGB3 Heterodimer, His Tag&Tag Free(IT3-R52E2) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 988 (ITGAM) & Ser 27 - Asp 717 (ITGB3) (Accession # NP_001385621.1 (ITGAM) & Q8R2H2 (ITGB3)).
    Predicted N-terminus: Phe 31 | Ser 27
  • Molecular Characterization

    Rat ITGAV&ITGB3 Heterodimer, His Tag&Tag Free, has a calculated MW of 112.3 kDa (ITGAV) & 81.6 kDa (ITGB3). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB3 contains no tag but a basic tail at the C-terminus.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris,150 mM NaCl,pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Integrin alpha V beta 3 SDS-PAGE

Rat ITGAV&ITGB3 Heterodimer, His Tag&Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Integrin alpha V beta 3 MALS images

The purity of Rat ITGAV&ITGB3 Heterodimer, His Tag&Tag Free (Cat. No. IT3-R52E2) is more than 85% and the molecular weight of this protein is around 210-240kDa verified by SEC-MALS.

Bioactivity-ELISA
 Integrin alpha V beta 3 ELISA

Immobilized Human Vitronectin, Tag Free (Cat. No. VIN-H5119) at 5 μg/mL (100 μL/well) can bind Rat ITGAV&ITGB3 Heterodimer, His Tag&Tag Free (Cat. No. IT3-R52E2) with a linear range of 0.039-1.25 μg/mL (QC tested).

  • Background
    Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus. Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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