Mouse NKG2A&CD94 Protein, Fc Tag

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Cat. No. / Size
Price
Qty
NC4-M5254-100ug
$395.00
NC4-M5254-1mg (500ug X 2)
$2500.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    NKG2A & CD94

  • Source

    Mouse NKG2A&CD94, Fc Tag (NC4-M5254) is expressed from human 293 cells (HEK293). It contains AA Thr 95 - Ile 244 (NKG2A) & Ile 32 - Ile 179 (CD94) (Accession # Q9Z202-1 (NKG2A) & O54707-1 (CD94)).

  • Molecular Characterization

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 61.3 kDa. The protein migrates as 70-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    NKG2A & CD94 SDS-PAGE

    Mouse NKG2A&CD94, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

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Background

CD94 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. NKG2A/CD159a is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors that inhibits innate immune system activation. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.

Recent Advances

 
Drug Development Progress
  • English Name:

    NK cell lectin-like receptor subfamily C member 1

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    6 Details

  • Highest Development Stage:

    Phase 3 Clinical

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