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Your Position: Home > Cytokines > IL-17 RC > ILC-H82F9

Biotinylated Human IL-17 RC Protein, Fc,Avitag™(MALS verified)

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Based on the high binding affinity between biotin-streptavidin systems, our Streptavidin series products are recommended to use together with biotinylated proteins to get lower non-specific binding results in a shorter time.
  • Synonym
    IL-17 RC,IL-17RC,IL17Rhom,IL-17 receptor C,IL-17RL,ZcytoR14
  • Source
    Biotinylated Human IL-17 RC, Fc,Avitag (ILC-H82F9) is expressed from human 293 cells (HEK293). It contains AA Leu 21 - His 465 (Accession # Q8NAC3-2).
    Predicted N-terminus: Leu 21
  • Molecular Characterization
    Online(Leu 21 - His 465) Q8NAC3-2

    This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 77.6 kDa. The protein migrates as 80-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Biotinylation
    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
  • Biotin:Protein Ratio
    Passed as determined by the HABA assay / binding ELISA.
  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Biotinylated Human IL-17 RC, Fc,Avitag (Cat. No. ILC-H82F9) SDS-PAGE gel

Biotinylated Human IL-17 RC, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Biotinylated Human IL-17 RC, Fc,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human IL-17 RC, Fc,Avitag (Cat. No. ILC-H82F9) is more than 85% and the molecular weight of this protein is around 195-240 kDa verified by SEC-MALS.

Bioactivity-ELISA
Biotinylated Human IL-17 RC, Fc,AvitagBiotinylated Human IL-17 RC, Fc,Avitag (Cat. No. ILC-H82F9) ELISA bioactivity

Immobilized Human IL17A, Tag Free (Cat. No. ILA-H5219) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-17 RC, Fc,Avitag (Cat. No. ILC-H82F9) with a linear range of 0.01-0.156 μg/mL (QC tested).

Biotinylated Human IL-17 RC, Fc,AvitagBiotinylated Human IL-17 RC, Fc,Avitag (Cat. No. ILC-H82F9) ELISA bioactivity

Immobilized Biotinylated Human IL-17 RC, Fc,Avitag (Cat. No. ILC-H82F9) at 5 μg/mL (100 μL/well) can bind Human IL17A, Tag Free (Cat. No. ILA-H5219) with a linear range of 0.01-0.078 μg/mL (Routinely tested).

  • Background
    Interleukin-17 receptor C (IL-17 RC), also known as IL17Rhom, IL-17RL, is the receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. IL-17A activity is inhibited by IL-17RA, IL-17F is inhibited by IL-17RC, and a combination of soluble IL-17RA/IL-17RC receptors is required for inhibition of the IL-17F/IL-17A activity. Furthermore, activation of IL17RC can lead to the induction of expression of inflammatory chemokines and cytokines such as CXCL1.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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