Login Register
icon_bulk_orderBulk order Acrobiosystems for English
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Aneuro > Alpha-Synuclein > ALN-C52H5

Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)

  • Synonym
    SNCA,NACP,PARK1,alpha-Synuclein
  • Source
    Cynomolgus Alpha-Synuclein, His Tag (ALN-C52H5) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # P61142-1).
    Predicted N-terminus: Met 1
  • Molecular Characterization
    Online(Met 1 - Ala 140) P61142-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 16.4 kDa. The protein migrates as 18-20 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 100 mM NaAC, pH7.0. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus Alpha-Synuclein, His Tag (Cat. No. ALN-C52H5) SDS-PAGE gel

Cynomolgus Alpha-Synuclein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Cynomolgus Alpha-Synuclein, His Tag (Cat. No. ) MALS images

The purity of Cynomolgus Alpha-Synuclein, His Tag (Cat. No. ALN-C52H5) is more than 90% and the molecular weight of this protein is around 14-20 kDa verified by SEC-MALS.

Bioactivity-ELISA
Cynomolgus Alpha-Synuclein, His TagCynomolgus Alpha-Synuclein, His Tag (Cat. No. ALN-C52H5) ELISA bioactivity

Immobilized Cynomolgus Alpha-Synuclein, His Tag (Cat. No. ALN-C52H5) at 1 μg/mL (100 μL/well) can bind Anti-Synucelin alpha/beta Monoclonal Antibody with a linear range of 0.004-0.25 μg/mL (QC tested).

  • Background
    Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Comments (0)


ETD of in-stock products: 2 business days

Price(USD) : $180.00

Price(USD) : $675.00

Promotion & Exhibitions



Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:12 Details
  • Latest Research Phase:Phase 2 Clinical

Datasheet & Documentation

Request for DMF
DMF (Drug Master File)

Contact Us

+1  800-810-0816 (US)
+86 400-682-2521 (AP)

Related Products

New Product Launch

Questions & Comments

This web search service is supported by Google Inc.

totop
Call us
Call us
North America: +1 800-810-0816 (Toll Free)
Asia & Pacific: +86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message