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Your Position: Home > Aneuro > Alpha-synuclein > ALN-M52H6

Mouse Alpha-Synuclein Protein, His Tag (MALS verified)

  • Source
    Mouse Alpha-Synuclein, His Tag(ALN-M52H6) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # O55042-1 ).
    Predicted N-terminus: Met
  • Molecular Characterization
    Alpha-synuclein Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 16.4 kDa. The protein migrates as 19-21 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 100 mM NaAC, pH7.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Alpha-synuclein SDS-PAGE

Mouse Alpha-Synuclein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Alpha-synuclein MALS images

The purity of Mouse Alpha-Synuclein, His Tag (Cat. No. ALN-M52H6) is more than 90% and the molecular weight of this protein is around 15-23 kDa verified by SEC-MALS.

Bioactivity-ELISA
 Alpha-synuclein ELISA

Immobilized Mouse Alpha-Synuclein, His Tag (Cat. No. ALN-M52H6) at 1 μg/mL (100 μL/well) can bind Anti-Synucelin alpha/beta Monoclonal Antibody with a linear range of 0.004-0.25 μg/mL (QC tested).

  • Background
    Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinsons disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $180.00

Price(USD) : $675.00

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  • Number of Drugs in Clinical Trials:12 Details
  • Latest Research Phase:Phase 2 Clinical

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