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Your Position: Home > Aneuro > Alpha-synuclein > ALN-H5214

Human Alpha-Synuclein Protein, Tag Free (MALS verified)

  • Source
    Human Alpha-Synuclein, Tag Free(ALN-H5214) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1 ).
    Predicted N-terminus: Met
  • Molecular Characterization
    Alpha-synuclein Structure

    This protein carries no "tag"

    The protein has a calculated MW of 14.5 kDa. The protein migrates as 15-16 kDa under reducing (R) condition (SDS-PAGE) .

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM HEPES, 100 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped as sterile liquid solution with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
SDS-PAGE
Alpha-synuclein SDS-PAGE

Human Alpha-Synuclein, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
Alpha-synuclein MALS images

The purity of Human Alpha-Synuclein, Tag Free(Cat. No. ALN-H5214) is more than 90% and the molecular weight of this protein is around 13-19 kDa verified by SEC-MALS.

Bioactivity-ELISA
 Alpha-synuclein ELISA

Immobilized Human Alpha-Synuclein, Tag Free (Cat. No. ALN-H5214) at 1 μg/mL (100 μL/well) can bind Synuclein alpha/beta Monoclonal Antibody with a linear range of 0.1-8 ng/mL (QC tested).

  • Background
    Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinsons disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:12 Details
  • Latest Research Phase:Phase 2 Clinical

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