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Your Position: Home > Protein > TL1A > TLA-C5241

Cynomolgus/Rhesus macaque TL1A / TNFSF15 Protein, His Tag

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  • Synonym
    TL1A, VEGI, TNFSF15
  • Source
    Cynomolgus/Rhesus macaque TL1A / TNFSF15, His Tag (TLA-C5241) is expressed from human 293 cells (HEK293). It contains AA Leu 72 - Leu 251 (Accession # F6S8F9-1 ).
    Predicted N-terminus: His
  • Molecular Characterization
    TL1A Structure

    This protein carries a polyhistidine tag at the N-terminus

    The protein has a calculated MW of 22.3 kDa. The protein migrates as 27-28 kDa and 29-31 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
TL1A SDS-PAGE

Cynomolgus/Rhesus macaque TL1A / TNFSF15, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
 TL1A ELISA

Immobilized Cynomolgus/Rhesus macaque TL1A / TNFSF15, His Tag (Cat. No. TLA-C5241) at 5 μg/mL (100 μL/well) can bind Human DcR3, Fc Tag (Cat. No. TNB-H5255) with a linear range of 0.2-10 ng/mL (QC tested).

 TL1A ELISA

Immobilized Human DcR3, Fc Tag (Cat. No. TNB-H5255) at 5 μg/mL (100 μL/well) can bind Cynomolgus/Rhesus macaque TL1A / TNFSF15, His Tag (Cat. No. TLA-C5241) with a linear range of 0.3-10 ng/mL (Routinely tested).

  • Background
    TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.
  • Clinical and Translational Updates

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