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Your Position: Home > Aneuro > Nogo Receptor > NOR-H52H3

Human Nogo Receptor / NgR Protein, His Tag (SPR verified)

  • Synonym
    Reticulon-4 receptor,Nogo-66 receptor
  • Source
    Human Nogo Receptor, His Tag(NOR-H52H3) is expressed from human 293 cells (HEK293). It contains AA Cys 27 - Ser 447 (Accession # Q9BZR6-1 ).
  • Molecular Characterization
    Nogo Receptor Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 47.3 kDa. The protein migrates as 61-68 kDa and 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Nogo Receptor SDS-PAGE

Human Nogo Receptor, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-SPR
 Nogo Receptor SPR

Human MAG, Fc Tag (Cat. No. MAG-H5254) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human Nogo Receptor, His Tag (Cat. No. NOR-H52H3) with an affinity constant of 7.52 μM as determined in a SPR assay (Biacore 8K) (QC tested).

 Nogo Receptor SPR

Human Nogo Receptor, His Tag (Cat. No. NOR-H52H3) immobilized on CM5 Chip can bind Human MAG, Fc Tag (Cat. No. MAG-H5254) with an affinity constant of 16.5 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).​

  • Background
    Nogo receptor/Reticulon-4 receptor plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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