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Your Position: Home > Protein > TGF-beta RI > TG1-H5259

Human TGFR-1 / ALK-5 / TGF-beta receptor type-1 Protein, Llama IgG2b Fc Tag (SPR verified)

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  • Synonym
    TGFR-1, ALK-5, TGF-beta receptor type-1, Activin receptor-like kinase 5
  • Source
    Human TGF-beta RI Protein, Llama IgG2b Fc Tag(TG1-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 34 - Leu 126 (Accession # P36897-1).
    Predicted N-terminus: Leu 34
  • Molecular Characterization
    TGF-beta RI Structure

    This protein carries a llama IgG2b Fc tag at the C-terminus

    The protein has a calculated MW of 38.0 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 51 mM Tris,100 mM Glycine,25 mM Arginine,150 mM NaCl,pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

Human TGF-beta RI Protein, Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

 TGF-beta RI SPR

Biotinylated Human TGF-Beta 1, Avitag (Cat. No. TG1-H8217) immobilized on SA Chip can bind Human TGF-beta RI, Llama IgG2b Fc Tag (Cat. No. TG1-H5259) with an affinity constant of 83.7 nM as determined in a SPR assay (Biacore 8K) (QC tested).

  • Background
    TGF type I receptor also called the activin receptor-like kinase 5 (ALK5) and involved in TGF signaling. TGFβ signaling is mediated by the interaction of TGFβ ligands (TGFβ 1, 2 or 3) with cell surface receptors, the TGF type I, type II and type III receptors. Signaling is initiated by binding of TGF to the TGF type II receptor forming a ligand-receptor complex which interacts with the TGF type I receptor.
  • Clinical and Translational Updates

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