Biotinylated Monoclonal Anti-TNF-alpha Antibody, human IgG1 (16H5)

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TNA-BLM494-100ug
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Source

Chimeric Biotinylated Monoclonal Anti-TNF-alpha Antibody, human IgG1 (16H5) is recombinantly expressed in HEK293. It consists of mouse variable regions genetically fused to human IgG1 constant domains.

Antibody Type

Recombinant Monoclonal

Clone

16H5

Isotype

Human IgG1, Kappa

Host Species

Mouse

Reactivity

Human

Immunogen

Human TNF-alpha Protein is expressed from human 293 cells

Conjugate

Biotinylated

Specificity

This product is a specific antibody specifically reacts with TNF-alpha.

Purification

Protein A purified.

Aggregation

Less than 10%, as determined by SEC-MALS.

Concentration

Please refer to the Certificate of Analysis (CoA).

Form

Lyophilized

Formulation

Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

Please contact us for customized product forms or formulations.

Reconstitution

Please refer to the Certificate of Analysis (CoA) for specific instructions.

Shipping

Lyophilized product is shipped at ambient temperature.

Storage

For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
Notices

Product Specific Notices: For research use only.

Background

Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.