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Human Oncostatin M (OSM) (26-221) Protein, premium grade

AIDD‑Ready
Cat. No. / Size
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OSM-H5214-20ug
$410.00
In Stock - Delivery in 1-2 business days
OSM-H5214-50ug
$795.00
In Stock - Delivery in 1-2 business days
OSM-H5214-1mg (500ug X 2)
$2,885.00
In Stock - Delivery in 1-2 business days
OSM-H5214
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

OSM, MGC20461, Oncostatin M

Source

Human Oncostatin M (OSM) (26-221) Protein, premium grade (OSM-H5214) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Arg 221 (Accession # P13725).

Predicted N-terminus: Ala 26

It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries no "tag".

The protein has a calculated MW of 22.2 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 0.1 EU per μg by the LAL method / rFC method.

Sterility

Negative

Mycoplasma

Negative

Purity

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Oncostatin M (OSM) serves as a critical maturation factor during the definitive endoderm-to-hepatocyte differentiation of human iPSCs/ESCs. Applied at the hepatoblast-to-hepatocyte transition stage—typically together with HGF and dexamethasone—OSM activates the gp130/LIFRβ receptor complex and downstream JAK/STAT3 and MAPK pathways. This drives robust upregulation of mature hepatic markers including ALB, major CYP enzymes (e.g., CYP3A4, CYP1A2), and bile acid transporters, thereby conferring drug-metabolizing, albumin-secreting, and detoxification capacities essential for functional hepatocyte-like cells and liver organoid models.