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Your Position: Home > Protein > IFN-alpha/beta R2 > IFA-R52H1

Rat IFN-alpha/beta R2 Protein, His Tag

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  • Synonym
    IFNAR2,IFNARB,IFNABR,IFN-R-2,IFN-alpha,beta receptor 2
  • Source
    Rat IFN-alpha/beta R2 Protein, His Tag(IFA-R52H1) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Ala 244 (Accession # M0R8H7-1 ).
    Predicted N-terminus: Phe 31
  • Molecular Characterization
    IFN-alpha/beta R2 Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 26.7 kDa. The protein migrates as 34-44 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
IFN-alpha/beta R2 SDS-PAGE

Rat IFN-alpha/beta R2 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Interferon alpha/beta receptor 2 (IFR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFBR and IFRB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. IFR2 can associate with IFR1 to form the type I interferon receptor. IFR2 is a receptor for interferons alpha and beta.IFR2 involves in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 of IFR2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 of IFR2 is a potent inhibitor of type I IFN receptor activity.Genetic variations in IFR2 influence susceptibility to hepatitis B virus (HBV) infection.
  • Clinical and Translational Updates

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ETD of in-stock products: 2 business days

Price(USD) : $350.00

Price(USD) : $2310.00

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