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Your Position: Home > Cytokines > IL-21 R & IL-2 R gamma > ILA-H52W9

Human IL-21 R & IL-2 R gamma Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

  • Synonym
    IL-21 R & IL-2 R gamma,IL21R & IL2RG,IL-21R & IL-2RG
  • Source
    Human IL-21 R & IL-2 R gamma Heterodimer Protein, Fc Tag&Fc Tag(ILA-H52W9) is expressed from human 293 cells (HEK293). It contains AA Cys 20 - Pro 236 (IL-21 R) & Leu 23 - Asn 254 (IL-2 R gamma) (Accession # Q9HBE5-1 (IL-21 R) & P31785-1 (IL-2 R gamma)).
    Predicted N-terminus: Cys 20 (IL-21 R) & Leu 23 (IL-2 R gamma)
  • Molecular Characterization
    IL-21 R & IL-2 R gamma Structure

    The protein has a calculated MW of 51.5 kDa (IL-21 R) & 53.6 kDa (IL-2 R gamma). The protein migrates as 65 kDa and 70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
IL-21 R & IL-2 R gamma SDS-PAGE

Human IL-21 R & IL-2 R gamma Heterodimer Protein, Fc Tag&Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
IL-21 R & IL-2 R gamma MALS images

The purity of Human IL-21 R & IL-2 R gamma Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILA-H52W9) is more than 85% and the molecular weight of this protein is around 128-156kDa verified by SEC-MALS.

Bioactivity-ELISA
 IL-21 R & IL-2 R gamma ELISA

Immobilized Human IL-21, Tag Free (Cat. No. IL1-H5213) at 5 μg/mL (100 μL/well) can bind Human IL-21 R & IL-2 R gamma Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILA-H52W9) with a linear range of 5-78 ng/mL (QC tested).

  • Background
    Interleukin (IL)-21, IL-2, IL-4, IL-7, IL-9, and IL-15 form a family of cytokines based on their sharing the common cytokine receptor γ chain (γc), which was originally discovered as the third receptor component of the IL-2 receptor,IL-2RG. IL-21 is a class I cytokine that exerts pleiotropic effects on both innate and adaptive immune responses. It signals through a heterodimeric receptor complex consisting of the IL-21 receptor (IL-21R) and the common γ-chain.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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