Human Transferrin R2 alpha Protein, Fc Tag

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Cat. No. / Size
Price
Qty
TRA-H5263-100ug
$310.00
TRA-H5263-1mg (100ug X 10)
$2040.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    TfR2

  • Source

    Human Transferrin R2 alpha, Fc Tag (TRA-H5263) is expressed from human 293 cells (HEK293). It contains AA Gly 112 - Phe 801 (Accession # Q9UP52-1).

    Predicted N-terminus: Pro

    Request for sequence
  • Molecular Characterization

    Transferrin R2 alpha Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 102.8 kDa. The protein migrates as 120-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Transferrin R2 alpha SDS-PAGE

    Human Transferrin R2 alpha, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     Transferrin R2 alpha ELISA

    Immobilized Human Transferrin R2 alpha, Fc Tag (Cat. No. TRA-H5263) at 1 μg/mL (100 μL/well) can bind TFR2 Antibody, Rabbit IgG with a linear range of 0.001-0.25 μg/mL (QC tested).

    Protocol

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Background

Transferrin R2 alpha, also known as TfR2α, is a type II transmembrane protein localized to the cell membrane and is primarily expressed in hepatocytes and erythroid precursors. Its functions include the uptake of iron-bound transferrin, acting as an iron-level sensor to regulate hepcidin for maintaining systemic iron homeostasis, and negatively regulating erythropoiesis. This protein is closely associated with diseases such as type 3 hereditary hemochromatosis, anemia, and β-thalassemia.

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