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Your Position: Home > Protein > Integrin alpha 8 beta 1 > IT1-R53W6

Rat ITGA8 & ITGB1 Heterodimer Protein, His Tag&Tag Free

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  • Synonym
    Integrin alpha 8 beta 1,ITGA8&ITGB1
  • Source
    Rat ITGA8 & ITGB1 Heterodimer Protein, His Tag&Tag Free(IT1-R53W6) is expressed from CHO cells. It contains AA Phe 38 - Pro 1034 (ITGA8) & Gln 21 - Asp 729 (ITGB1) (Accession # F7F1E3 (ITGA8) & P49134 (ITGB1)).
    Predicted N-terminus: Phe 38 (ITGA8) & Gln 21 (ITGB1)
  • Molecular Characterization
    Integrin alpha 8 beta 1 Structure

    Rat ITGA8 & ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA8 and ITGB1, has a calculated MW of 117.2 kDa (ITGA8) and 83.7 kDa (ITGB1). The protein migrates as 50-55 kDa and 65-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >80% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Integrin alpha 8 beta 1 SDS-PAGE

Rat ITGA8 & ITGB1 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 80% (With Star Ribbon Pre-stained Protein Marker).

  • Background
    Human Integrin alpha 8 beta 1 Heterodimer Protein consists of ITGA8 and ITGB1. The integrin alpha 8 subunit, isolated by low stringency hybridization, is a novel integrin subunit that associates with beta 1. The recently identified alpha 8 integrin subunit associates with beta 1 and is predominantly expressed in smooth muscle and other contractile cells in adult tissues, and in mesenchymal and neural cells during development. In addition, Integrin alpha 8 beta 1 is a receptor for fibronectin and can promote attachment, cell spreading, and neurite outgrowth on fibronectin.
  • Clinical and Translational Updates

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