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Your Position: Home > Protein > LRP-1 > LR1-H5256

Human LRP-1 / cluster Ⅳ Protein, Fc Tag

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  • Synonym
    A2MR, APOER, APR, CD91, IGFBP-3R, IGFBP3R, IGFBP3R1, KPA, LRP, LRP1A, TGFBR5
  • Source
    Human cluster Ⅳ Protein, Fc Tag(LR1-H5256) is expressed from human 293 cells (HEK293). It contains AA Ser 3332 - Asp 3779 (Accession # Q07954-1 ).
    Predicted N-terminus: Ser 3332
  • Molecular Characterization
    LRP-1 Structure

    This protein carries a human IgG1 Fc tag at the C-terminus

    The protein has a calculated MW of 76.6 kDa. The protein migrates as 95-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
LRP-1 SDS-PAGE

Human cluster Ⅳ Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-BLI
 LRP-1 BLI

Loaded Unconjugated Human PDGF-BB, His,Avitag (Cat. No. PDB-H5127) on NTA Biosensor, can bind Human cluster Ⅳ Protein, Fc Tag (Cat. No. LR1-H5256) with an affinity constant of 4.82nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

  • Background
    Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor. LRP1 is also a key signalling protein and, thus, involved in various biological processes, such as lipoprotein metabolism and cell motility, and diseases, such as neurodegenerative diseases, atherosclerosis, and cancer.
  • Clinical and Translational Updates

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  • Latest Research Phase:Preclinical

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