Login Register
icon_bulk_orderBulk order Acrobiosystems for English
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Protein > GCGR > GCR-H53H3

Human GCGR / Glucagon receptor Protein, Fc Tag (MALS verified)

  • Synonym
    Glucagon R, GCGR,Glucagon receptor
  • Source
    Human GCGR Protein, Fc Tag(GCR-H53H3) is expressed from CHO cells. It contains AA Ala 26 - Lys 136 (Accession # P47871-1 ).
    Predicted N-terminus: Ala 26
  • Molecular Characterization
    GCGR Structure

    This protein carries a human IgG1 Fc tag at the C-terminus

    The protein has a calculated MW of 39.5 kDa. The protein migrates as 52-62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 0.01 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

Human GCGR Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

GCGR MALS images

The purity of Human GCGR Protein, Fc Tag (Cat. No. GCR-H53H3) is more than 90% and the molecular weight of this protein is around 100-115 kDa verified by SEC-MALS.


Immobilized Human GCGR Protein, Fc Tag (Cat. No. GCR-H53H3) at 1 μg/mL (100 μL/well) can bind Anti-GCGR Antibody,Human IgG4 with a linear range of 0.5-16 ng/mL (QC tested).


Immobilized Human GCGR Protein, Fc Tag (Cat. No. GCR-H53H3) at 1 μg/mL (100 μL/well) can bind Anti-GCGR Antibody,Human IgG2 with a linear range of 0.2-16 ng/mL (Routinely tested).


Human GCGR Protein, Fc Tag (Cat. No. GCR-H53H3) immobilized on CM5 Chip can bind GLP-1 (7-37) with an affinity constant of 51.1 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

  • Background
    G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Comments (0)

ETD of in-stock products: 2 business days

Price(USD) : $350.00

Price(USD) : $2800.00

Promotion & Exhibitions

Drug Development Status

  • Number of Launched Drugs:6 Details
  • Number of Drugs in Clinical Trials:24 Details
  • Latest Research Phase:Approved

Datasheet & Documentation

Request for DMF
DMF (Drug Master File)

Contact Us

+1  800-810-0816 (US)
+86 400-682-2521 (AP)

Related Products

New Product Launch

Questions & Comments

This web search service is supported by Google Inc.

Call us
Call us
North America: +1 800-810-0816 (Toll Free)
Asia & Pacific: +86 400-682-2521
+1 888-377-6111
1 Innovation Way, Newark, DE 19711, USA

Leave a message