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Your Position: Home > Protein > DLL3 > DL3-HP2H7

PE-Labeled Human DLL3 Protein, His Tag (Site-specific conjugation)

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  • Synonym
    Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3
  • Source
    PE-Labeled Human DLL3 Protein, His Tag (DL3-HP2H7) is produced via site-specific conjugation of PE to Human DLL3 Protein, His Tag under optimal conditions with a proprietary technology. Human DLL3 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Leu 492 (Accession # Q9NYJ7-1).
    Predicted N-terminus: Ala 27
  • Molecular Characterization
    DLL3 Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 52.1 kDa.

  • Conjugate

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • Application
    Please note that this product is NOT compatible to streptavidin detection system.
  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Bioactivity-FACS
 DLL3 FACS

5e5 of anti-DLL3 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human DLL3 Protein, His Tag (Cat. No. DL3-HP2H7) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

  • Background
    Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.
  • Clinical and Translational Updates

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ETD of in-stock products: 2 business days

Price(USD) : $335.00

Price(USD) : $2080.00

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  • Latest Research Phase:NDA/BLA

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